CUNY School of Medicine
Left: Expression of glt-3 in the canal cell    Right: Expression of glt-1 around the nerve ring







1. Del Rosario, J., Feldmann, K.G., Ahmed, T., Amjad, U., An, JH, Mahmud, T., & Mano, I. (2015). Death Associated Protein Kinase (DAPk) –Mediated Cell Death Mechanisms in Nematode Excitotoxicity. BMC Neurosci 16:25 .
(Paper selected as one of the 10 most influential manuscripts of the year for this journal).    PMID:    25899010


2. Tehrani, N., Del Rosario, J., Dominguez, M., Kalb, R, and Mano, I., (2014). The Insulin/IGF Signaling Regulators Cytohesin/GRP-1 and PIP5K/PPK-1 Modulate Susceptibility to Excitotoxicity in C. elegans. PLoS One 9(11):e113060     PMID:   25422944


3. Mano, I.UU, and Driscoll, M., (2009) C. elegans Glutamate Transporter Deletion Induces AMPA-Receptor/Adenylyl Cyclase 9-Dependent Excitotoxicity. J. Neurochem. 108:1373-1384.      PMID: 19054279

4. Mojsilovic-Petrovic, J., Nedelsky, N., UUMano, I.UU, Georgiades, S.N., Zhou, W., Liu, Y., Neve, R.L., J.P., Driscoll, M., Merry, D., and Kalb, R.G.,(2009). FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J. Neurosci., 29: 8236-8247.      PMID: 19553463


5. UUMano, I.UU, Straud, S., and Driscoll, M. (2007). C. elegans glutamate transporters influence synaptic function and behavior at sites distant from the synapse. J Biol Chem 282: 34412-34419.      PMID: 17681948

6. Hong, K. UUMano, IUU. and Driscoll, M. (2000). In-vivo structure/function analysis of C. elegans candidate mechanotransducing ion channel subunit MEC-4. J. Neurosci. 20: 2575-2588.      PMID: 10729338

7. UUMano, IUU. and Driscoll, M. (1999). The DEG/ENaC Channels: A touchy superfamily that watches its salt. BioEssays 21 (7): 568-578.      PMID: 10472184

8. Thieringer, H., Sahota, S., UUMano, IUU. and Driscoll, M. (1999). C. elegans degenerin channels: form and function. Curr. Top. Membr. 47: 297-314 .

9. UUMano, IUU. and Teichberg, V.I., (1998). A tetrameric subunit stoichiometry for a glutamate receptor/channel complex. NeuroReport 9: 327-331 .      PMID: 9507977


10. UUMano, I.UU, Lamed, Y. and Teichberg, V.I., (1996). A Venus flytrap mechanism for activation and desensitization of AMPA receptors. J. Biol. Chem. 271: 15299-15302.      PMID: 8663365

11. UUMano, .I.UU, Paperna, T., Devillers-Thiery, A., Galzi, J.-L., Changeux, J.-P., and Teichberg, V.I. (1993). A study of non-NMDA receptors in chick cerebellum. J. Neurochem. 61: S13D.

12. Gregor, P., Yang, X., UUMano, I.UU, Takemura, M., Teichberg, V. I. and Uhl, G. R. (1992). Organization and expression of the gene encoding chick kainate binding protein, a member of the glutamate receptor family. Mol. Brain Res. 16, 179-186.       PMID: 1337927

13. Teichberg, V.I., Lamed Y., Maoz I., UUMano I.UU, Ortega A., Paas Y., and Paperna T. (1992). Structure and regulation of the Bergmann glia kainate receptor. in Excitatory amino acids. Fidia Res. Found. Symp. Series. Thieme Medical Publishers, 9:35-40 .

14. Teichberg, V.I., Eshhar, N., Maoz, I., UUMano, I.UU, Ornstein, D., Ortega, A., Gregor, P. (1990). Molecular characterization, ultrastructural localization and gene cloning of the chick cerebellar kainate receptor. Adv Exp Med Biol 268:73-78 .      PMID: 1963755

15. Gregor, P., UUMano, I.UU, Maoz, I., McKeown, M. & Teichberg, V.I.(1989). Molecular structure of the chick cerebellar kainate-binding subunit of a putative glutamate receptor. Nature 342, 689-692.      PMID: 2480525

Physiol. Pharm. & Neurosci, City College, C. elegans @ CUNY


The Mano Lab

Department of Physiology, Pharmacology, & Neuroscience

Sophie Davis Biomedical School, City College, The City University of New York.